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. Author manuscript; available in PMC: 2015 Jun 17.
Published in final edited form as: Thromb Haemost. 2014 Jun 5;112(3):495–502. doi: 10.1160/TH14-01-0086

Figure 3. A2 binding in FVIIIa variants with E665L and E665I mutations.

Figure 3

WT FVIIIa and FVIIIa mutants with a substitution in the A2 subunit were reconstituted from WT and bA2 (20 nM) and the indicated concentrations of A1/A3C1C2, and FXa generation assays performed as described in the legend to Figure 2. Results were averaged from 4 separate determinations. WT, closed circles; E665L, closed triangles; E665I, closed squares.