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. 2015 Jun 5;13:135. doi: 10.1186/s12916-015-0381-9

Table 8.

Comparing rates of tuberculosis in 198,227 patients with type 2 diabetes (T2DM) and HbA1c measurements with a matched unexposed cohort

			Age adjusted		Fully adjusted model^a
Exposure group	Number of patients	TB cases/PY^b	Rate^c (95 % CI)	Rate ratio	Rate ratio	P-value*
Exposure group	(% of T2DM)	TB cases/PY^b	Rate^c (95 % CI)	(95 % CI)	(95 % CI)	P-value*
Patients without diabetes	1,088,376	689/50.97	13.51 (12.54–14.56)	1.00	1.00
Patients with T2DM
HbA1c mmol/mol (%):
≤48 (6.5)	61,336 (30.9)	50/2.86	17.48 (13.25–23.06)	1.29 (0.97–1.72)	1.34 (0.88–2.05)	0.140
49- ≤ 58 (6.5–7.5)	70,470 (35.6)	54/3.98	13.57 (10.39–17.72)	1.00 (0.76–1.32)	1.14 (0.76–1.70)
>58 (>7.5)	66,421 (33.5)	71/3.99	17.81 (14.12–22.48)	1.32 (1.03–1.68)	1.50 (1.04–2.17)

*P-value from likelihood ratio test

^aModel adjusted for: age, BMI, smoking status, alcohol status, ethnicity and IMD

^bPY: 100,000 person years at risk

^cRate: per 100,000 person years

BMI body mass index, CI confidence interval, IMD index of multiple deprivation, TB tuberculosis