Table 5.

PK/PD Modeling of ex-vivo data after administration of Cefquinome in cattle (n = 6).

Parameters	Unit	Mean
E0	Log10 CFU/ml	2.93
EMAX	Log10 CFU/ml	−5.33
EMAX-E0	Log10 CFU/ml	8.26
Slope (N)	–	2.74
AUC24 h/MIC EC50	h	36.96
AUC24 h/MIC for bacteriostatic action	h	29.71
AUC24 h/MIC for bactericidal action (99.9% reduction)	h	51.97
AUC24 h/MIC for bacterial eradication (99.99% reduction)	h	67.51

E₀, difference in bacterial count in control sample (without drug) between 0 and 24 h; E_max, difference in bacterial count in sample incubated with Cefquinome between 0 and 24 h; AUC₂₄h/MIC EC₅₀:AUC₂₄h/MIC of drug producing 50% of maximal antibacterial effect; N, slope of the AUC₂₄h/MIC–response curve.