Figure 1.

Haemoglobin, haematocrit, creatinine, and lactate dehydrogenase profiles from both hospital admissions. The first admission for severe malaria with hyperparasitaemia and hyperbilirubinaemia from day 0 to day 8; second hospital admission for severe haemolytic anaemia and acute kidney injury from day 20 to day 44. a Haemoglobin and haematocrit profile during hospital admissions. Haematocrit was stable during first hospital admission. Haemoglobin dropped by 57 and 65% on days 14 and 20, respectively, and recovered by day 81. Arrows indicate timing of whole blood transfusions on days 20 and 21; b haemoglobin and lactate dehydrogenase (LDH) profile during hospital admissions; c haemoglobin and creatinine profile during hospital admissions. Acute kidney injury, with a creatinine increase by 21× on second hospital admission, classified as stage 3 according to AKIN criteria and ‘failure’ by RIFLE criteria. Presumed baseline creatinine from day 1 was 74 μmol/L. His creatinine returned close to baseline by day 81 (106 μmol/L). Asterisks indicate haemodialysis on days 20, 21, 23, 25, and 30; ‘B’ indicates renal biopsy on day 27. AKIN acute kidney injury network, RIFLE risk, injury, failure, loss, end-stage kidney disease.