Table 5. Comparison of saliva with other body fluids / tissue for measurement of various analytes in selected pathological conditions.

Conditions	Comparison carried out	Markers / analytes	Correlations observed	Remarks	Reference
Head and neck cancer	Saliva – tumor tissue	Mitochondrial DNA	Positive	Increased levels that decreased in post-surgical condition	(47)
OSCC	Saliva-serum	p53 antibody	Positive	Saliva may offer a specific method for detection of a subset of OSCC with p53 aberrations	(48)
Malignant ovarian tumors	Saliva-serum	CA 125	Positive	Saliva assay showed better assay value than serum	(63)
Breast cancer	Saliva-serum	Cellular erythroblastosis oncogene B-2 (c-erbB-2)	Positive	ErbB-2 protein may have potential use in the initial detection and/or follow-up screening of breast cancer in women	(3)
Dengue	Saliva-serum	Dengue antibody	Positive	Saliva as an alternative for dengue diagnosis	(50)
Sjögren’s syndrome	Saliva- serum	C-X-C motif chemokine 13	Positive	CXCL13 may provide an innovative approach for managing this disease	(3)
HIV	Saliva-serum	HIV antibody	Positive	Formulation of a commercially available diagnostic kit OraQuick	(63)

EGF - epidermal growth factor; HIV - human immuno deficiency virus.