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Isogenic iPSCs from individual mosaic for trisomy 21 or from monozygotic twins discordant for trisomy 21. (A) Isogenic D21-iPSCs and T21-iPSCs have been derived from mosaic patients for trisomy 21 [19,20]; (B) Isogenic D21-iPSCs and T21-iPSCs have been generated from monozygotic twins discordant for trisomy 21 [22,23,24].
