Table 4.
Treatment strategies, treatment efficacy and clinical outcomes of postoperative hyponatremia seen in 62 patients after undergoing transsphenoidal resection of a pituitary mass at the authors’ institution between January, 2006, and December, 2012.
| Hyponatremia Treatment Strategies (N (%)) | |
|---|---|
| None | 30 (48.4) |
| Fluid restriction | 27 (43.5) |
| Diuretics (e.g., furosemide) | 19 (30.6) |
| Hypertonic saline | 9 (14.5) |
| Normal saline | 7 (11.3) |
| Sodium chloride tablets | 3 (4.8) |
| Demeclocycline | 2 (3.2) |
| Corticosteroids | 2 (3.2) |
| Conivaptan | 1 (1.6) |
| Time to Resolution of Hyponatremia (days) | |
| All 62 patients with hyponatremia | 3.5 ± 4.1 |
| By Severity | |
| Mild hyponatremia (N = 32) | 2.0 ± 2.8 |
| Moderate hyponatremia (N = 19) | 5.1 ± 5.1 |
| Severe hyponatremia (N = 11) | 5.3 ± 3.6 |
| By Etiology | |
| Hyponatremia due to desmopressin acetate overdose (N = 3) | 1.5 ± 0.9 |
| Hyponatremia due to SIADH (N = 44) | 3.7 ± 4.0 |
| Hyponatremia due to CSW (N = 15) | 4.3 ± 4.1 |
| By Treatment | |
| Conivaptan (N = 1) | 1 |
| Normal saline (N = 7) | 4 ± 2.4 |
| Corticosteroids (N = 2) | 4 ± 2.8 |
| Sodium chloride tabs (N = 3) | 4.7 ± 1.2 |
| Hypertonic saline (N = 9) | 4.8 ± 3.9 |
| Fluid restriction (N = 27) | 5.7 ± 4.8 |
| Demeclocycline (N = 2) | 6 ± 1.4 |
| Diuretics (e.g., furosemide) (N = 19) | 6.3 ± 5.1 |
| Clinical Outcomes of Hyponatremia (N (%)) | |
| Complete resolution of symptoms | 62 (100) |
| Persistent neurological deficit | 0 (0) |
| Death | 0 (0) |