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. 2014 Dec 29;4(1):37–65. doi: 10.3390/jcm4010037

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Several different types of cells have been used to produce iPSCs, including fibroblasts, neural progenitor cells, keratinocytes, melanocytes, CD34⁺ cells, cord blood cells and adipose stem cells. The next step, after generating iPSCs, towards the treatment of spinal cord injury (SCI) is to differentiate the iPSCs to the appropriate multipotent or differentiated cell type that can be used for the treatment of SCI. To date, several different cell types have been successfully derived from iPSCs and have been transplanted into SCI animal models, including neuronal progenitor cells, neurons, oligodendrocytes, astrocytes, neural crest cells and mesenchymal stromal cells.