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. 2015 Jun 1;29(11):1095–1105. doi: 10.1101/gad.263863.115

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© 2015 Schmidt and Cech Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — The telomerase catalytic cycle and its modulation by TPP1. Telomere extension requires multiple steps: primer DNA binding; extension of the primer using dGTP, TTP, and dATP as substrates; translocation of the RNA template relative to the active site and translocation of the DNA primer relative to the template; and recycling (thick arrow) for another round of extension. TPP1 aids translocation of the telomeric primer and reduces the rate of product dissociation from cycling telomerase to increase RAP.