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Model for NstA function. The activation of NstA (gray) by the formation of intermolecular cysteine disulfide bonds happens only when the cytoplasm is oxidized (green) and not in the reduced cell state (red). Upon activation, NstA inhibits the DNA decatenation activity of topo IV by specifically binding to the ParC (brown) subunit of the topo IV complex. The topo IV complex is a heterotetramer of ParC and ParE (orange).
