Figure 6. Effects of pulmonary rehabilitation mixture (PRM) on α-smooth muscle actin (α-SMA), fibroblast growth factor (FGF)-2, platelet-derived growth factor (PDGF), high mobility group protein B1 (HMGB1), and receptor for advanced glycation end-product (RAGE) expression in bleomycin (BLM)-treated animals. Representative light microscopic appearance of α-SMA and HMGB1 in lung tissue (immunostaining) for the normal (A1, B1), the model (A2, B2), and 3 g/kg PRM (A3, B3). C, Representative Western blots of α-SMA, FGF-2, PDGF, HMGB1 and RAGE. D, E, Effects of PRM on α-SMA, FGF-2, PDGF, HMGB1 and RAGE expression in BLM-treated lung by Western analysis. Data are reported as means±SD. PCNA: proliferating cell nuclear antigen. ^#P<0.01 vs the normal group; *P<0.01 vs the model group (one-way ANOVA followed by Dunnett's test).