1. Detailed search strategy.
| Search set | CIDG SRa | CENTRAL | MEDLINEb | EMBASEb | LILACSb |
| 1 | malaria | malaria | malaria | malaria | malaria |
| 2 | arte* | arte* | arte* | arte* | arte* |
| 3 | dihydroarte* | dihydroarte* | dihydroarte* | dihydroarte* | dihydroarte* |
| 4 | amodiaq* | amodiaq* | amodiaq* | amodiaq$ | amodiaq$ |
| 5 | lumefantrine | lumefantrine | lumefantrine | lumefantrine | lumefantrine |
| 6 | Coartem* | Coartem* | Coartem* | Coartem$ | Coartem$ |
| 7 | mefloquine | mefloquine | mefloquine | mefloquine | mefloquine |
| 8 | 2 or 3 | 2 or 3 | 2 or 3 | 2 or 3 | 2 or 3 |
| 9 | 4 or 5 or 6 or 7 | 4 or 5 or 6 or 7 | 4 or 5 or 6 or 7 | 4 or 5 or 6 or 7 | 4 or 5 or 6 or 7 |
| 10 | 1 and 8 and 9 | 1 and 8 and 9 | 1 and 8 and 9 | 1 and 8 and 9 | 1 and 8 and 9 |
| 11 | — | — | Limit 10 to humans | Limit 10 to human | — |
aCochrane Infectious Diseases Group Specialized Register. bSearch terms used in combination with the search strategy for retrieving trials developed by The Cochrane Collaboration (Lefebvre 2008); upper case: MeSH or EMTREE heading; lower case: free text term.