2. Primary outcome measure (Total failure).

Analysis	Participants	PCRb‐unadjusted		PCR‐adjusted
		Numerator	Denominator	Numerator	Denominator
Primary analysis	Exclusions after enrolmenta	Excludedc	Excluded	Excluded	Excluded
	Missing or indeterminate PCR	Included as failures	Included	Excluded	Excluded
	New infections	Included as failures	Included	Excluded	Excluded
Sensitivity analysis 1d	As 'Primary analysis' except: missing or indeterminate PCR	—	—	Included as failures	Included
Sensitivity analysis 2e	As 'Sensitivity analysis 1' except: new infections	—	—	Included as successes	Included
Sensitivity analysis 3f	As 'Sensitivity analysis 2' except: exclusions after enrolment	Included as failures	Included	Included as failures	Included
Sensitivity analysis 4g	As 'Sensitivity analysis 2' except: exclusions after enrolment	Included as successes	Included	Included as successes	Included

^aNote: participants who were found to not satisfy the inclusion criteria after randomization are removed from all calculations.
 ^bPCR: polymerase chain reaction.
 ^c'Excluded' means removed from the calculation.
 ^dTo re‐classify all indeterminate or missing PCR results as treatment failures in the PCR‐adjusted analysis.
 ^eTo re‐classify all PCR‐confirmed new infections as treatment successes in the PCR‐adjusted analysis. (This analysis may overestimate efficacy as PCR is not wholly reliable and some recrudescences may be falsely classified as new infections. Also some participants may have proceeded to develop a recrudescence after the new infection.)
 ^fTo re‐classify all exclusions after enrolment (losses to follow‐up, withdrawn consent, other antimalarial use, or failure to complete treatment) as treatment failures. For PCR‐unadjusted total failure, this represents a true worse‐case scenario.
 ^gTo re‐classify all exclusions after enrolment (losses to follow‐up, withdrawn consent, other antimalarial use, or failure to complete treatment) as treatment successes.