6. DHA‐P versus AS+MQ dosing regimens.
| Study ID | Year of study | Age limits | DHA‐P | AS+MQ |
| Ashley 2004a THA | 2003 | > 14 yrs | 6 mg/kg DHA + 48 mg/kg P in 4 divided doses at 0, 8, 24, and 48 hrs | 4 mg/kg AS once daily for 3 days + 8 mg/kg MQ once daily for 3 days. |
| Ashley 2004b THA | 2003 | 1 to 65 yrs | 6 mg/kg DHA + 48 mg/kg P in 4 divided doses at 0, 8, 24, and 48 hrs | 4 mg/kg AS once daily for 3 days + 8 mg/kg MQ once daily for 3 days. |
| Ashley 2005 THA | 2005 | 1 to 65 yrs | 6.4 mg/kg DHA and 51.2 mg/kg P in 4 divided doses at 0, 8, 24, and 48 hrs or 3 divided doses at 0, 24, and 48 hrs | 4 mg/kg AS once daily for 3 days + 8 mg/kg MQ once daily for 3 days. |
| Grande 2007 PER | 2005 | 5 to 60 yrs | Total dose: 6.3 mg/kg DHA and 50.4 mg/kg PQP in 3 divided doses, given once daily for 3 days | 4 mg/kg AS once daily for 3 days + 8 mg/kg MQ once daily for 3 days. |
| Janssens 2007 KHM | 2003 | > 1 yr |
Adult total dose: 6 mg/kg DHA and + 48 mg/kg P in 4 divided doses at 0, 8, 24, and 48 hrs Children total dose: 6.4 mg/kg DHA + 51.2 mg/kg P in 4 divided doses at 0, 8, 24, and 48 hrs |
Adults: 100 mg AS plus 500 mg MQ twice daily on day 0, 200 mg AS once daily on days 1 and 2. Children: 4 mg/kg AS once daily for 3 days + 25 mg/kg MQ in 2 equal doses on day 0. |
| Mayxay 2006 LAO | 2004 | > 1 yr | 6.3 mg/kg DHA + 50.4 mg/kg P in 3 divided doses, once daily for 3 days | 4 mg/kg AS once daily for 3 days + 15 mg MQ base/kg on day 1 and 10 mg base/kg on day 2. |
| Smithuis 2006 MMR | 2004 | > 1 yr | 6.3 mg/kg DHA + 50.4 mg/kg P in 3 divided doses, once daily for 3 days | 4 mg/kg AS once daily for 3 days. 25 mg MQ base/kg as a single dose on day 0. |
| Smithuis 2010 MMR | 2009 | > 1 yr | 2.5 mg/kg DHA + 20 mg/kg P daily, given once daily for 3 days |
Fixed combination: 4 mg/kg AS + 8.8 mg/kg MQ daily, once daily for 3 days. Loose combination: 4 mg/kg AS once daily for 3 days + 25 mg base/kg MQ as a single dose on day 0. |
| Tangpukdee 2005 THA | Not stated | > 14 yrs | 6 mg/kg DHA + 45 mg/kg P in 3 divided doses, given once daily for 3 days | 4 mg/kg AS once daily for 3 days + 8 mg/kg MQ once daily for 3 days. |
| Tran 2004 VNM | 2002 | > 2 yrs | 40 mg/320 mg tablets
Adults: 2 tablets at 0, 6, 24, and 48 hrs Children < 15 yrs: 1 tablet at 0, 6, 24, and 48 hrs |
4 mg/kg AS once daily for 3 days + 25 mg base/kg MQ as 2 divided doses 6 hrs apart on day 3. |
| Valecha 2010 AS | 2007 | 3m to 65 yrs (≥18 yrs in India) | DHA: 2.25 mg/kg DHA + 18 mg/kg P daily dose for 3 days | 4mg/kg AS once daily for 3 days + MQ none on day 0, then 15 mg/kg once on day 1 and 10 mg/kg once on day 2 |