10. DHA‐P versus AS+AQ: Biochemical monitoring and adverse events.

Study ID	No. of participnts	Tests	Days tested	Days reported	Days tested adequate?	For adequate testing, was reporting complete?	Results as presented in the paper
Karema 2006 RWA	762	LFTs at one site only	Days 0 and 14	None	Adequate1	Incomplete 2	"No hepatotoxicity was observed, although analyses were performed at one site only (data not shown)".
The 4ABC Study 2011 AF	2701	LFT and renal function	Days 7 and 28	Days 7 and 28	Adequate1	Complete3	"The median levels of alanine aminotransferase and creatinine before treatment, as well as the proportion of patients with values above the normal range (both clinically and non‐clinically significant, the latter not shown), were similar between the four study arms, and this did not change during the follow‐ups at day 7 and 28".

¹ Adequate given that no clinically important abnormalities were seen.
 ² Incomplete as trial authors did not present data and only gave a text summary.
 ³ Complete as trial authors presented data for the two days tested.