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. Author manuscript; available in PMC: 2016 Feb 16.
Published in final edited form as: Angew Chem Int Ed Engl. 2015 Jan 7;54(8):2410–2415. doi: 10.1002/anie.201411493

Figure 2.

Figure 2

a. Prior analog work. b. Stereochemical relay and high potency analogs via nitrosopurine-ene reaction. acytotoxicity against HT-29 cells (EC50 more appropriate).