Fig. 7.
SEC data supporting the formation of brushed-brushes incorporating chemical functionality suitable for binding SA-AB conjugates and bocprotected carbazate residues capable of binding doxorubcin (following deprotection with TFA) via hydrolytically cleavable hydrazone bonds. Molecular weight, Đ, and thiocarbonyl thio groups per polymer: (mCTA) 15,700/1.01/1, (gCTA Gen. 1) 20,100/1.12/9.30, (Brush Gen. 1) 140,000/1.19/n.d., (gCTA Gen. 2) 171,000/1.27/75.5, (Brush Gen. 2) 1,152,000/1.25/n.d. The average molecular weight per arm for the 1st and 2nd generation brush are 16,200 and 13,000 respectively. The average number of carbazate (following deptrotection) and biotin residues was determined to be 385 and 65 respectively.