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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Future Virol. 2015;10(2):155–167. doi: 10.2217/fvl.14.103

Figure 3. Structure of the human parvovirus B19 right-hand-inverted terminal repeat and the human parvovirus B19 minimal DNA replication origin (Ori).

Figure 3

The B19V right-hand ITR (R-ITR) at 365 nt is depicted in both the ‘Flip’ and the ‘Flop’ orientation, and the trs and NSBEs thought to comprise the NS1 binding site are indicated. The ITR is a nearly perfect palindromic structure; the exceptions are the three unpaired bases at two sites (shown as ‘bulges’) and three mismatched bases at three sites (shown as ‘bubbles’). The nucleotide sequences of the minimal B19V DNA replication origin (Ori) are indicated. The ITR sequence refers to the B19V J35 strain (GenBank accession number: AY386330).

B19V: Human parvovirus B19; ITR: Inverted terminal repeat; NSBE: NS1-binding element; trs: Terminal resolution site.