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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Invest Radiol. 2015 May;50(5):322–329. doi: 10.1097/RLI.0000000000000128

Figure 2.

Figure 2

Overview of experimental design. In 33 nude mice, subcutaneous human colon cancer xengrafts were randomized into three groups. In group 1 (n=19), two consecutive 3D USMI exams using MBVEGFR2 and MBControl each in random order in the same imaging session were performed to assess reproducibility of the imaging technique (total of 4 injections). Mice in group 2 (n=7) were scanned before and 24 hours after a single dose of bevacizumab; mice in group 3 (n=7) served as control group without anti-angiogenic treatment. After scanning, tumor tissues were harvested for ex vivo analysis.