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. 2015 Jun 17;10(6):e0130357. doi: 10.1371/journal.pone.0130357

Fig 2. In vivo imaging of hypoxia.

Fig 2

(A) The fluorescent probe HypoxiSense 680 was used to analyze hypoxia in vivo 21 days following tumor implantation. (B) Fluorescent signal was quantitated from tumor bearing mice (N = 5; *p < 0.05). Animals were imaged prior to injection to analyze tissue autofluorescence (“Before injection”; N = 5; ***p < 0.001). Non-tumor bearing mice were injected to analyze non-specific binding (“Normal Brain”; N = 2; *p < 0.05). (C) Tumor bioluminescence imaging showed no significant difference between SD and KC (N = 5).