Table 4.
| |||||
---|---|---|---|---|---|
entry | nucleophile | product | isolated yield (%) | ||
1 | 2a | R = CN 4a | 75 | ||
OME4a’ | 77 | ||||
2 | 2b | R = CN 4b | 72 | ||
OME4b’ | 74 | ||||
3 | 2c | R = CN 4c | 67 | ||
4 | 2d | R = CN 4d | 80 | ||
5 | 2f | R = CN 4f | 48 | ||
6 | 2g | R = CN 4g | 67 | ||
OME4g’ | 60 |
All reactions were carried out using 0.5mmol of aryl chloride and 0.55 mmol of alkoxymethyltrifluoroborate.