Table 4. Subsequent live birth rate in patients who underwent PGD or conceived naturally.
| 37 patients aged < = 34 years who underwent PGD | 52 patients who conceived naturally | OR (95% CI)* | p-value | |
|---|---|---|---|---|
| Live birth rate on the first trial | 37.8% (14/37) | 53.8% (28/52) | 0.52 (0.22–1.23) | 0.10 |
| Cumulative live birth rate | 67.6% (25/37) | 65.4% (34/52) | 1.10 (0.45–2.70) | 0.83 |
| Infertility | 18.9% (7) | 3.8% (2) | 1.19 (1.00–1.40) | 0.03 |
| Total (range) and mean number of further miscarriages until a live birth | 9 (0–1) and 0.24 ± 0.40 | 30 (0–3) and 0.58 ± 0.78 | - | 0.02 |
| Biochemical pregnancy* | 1 | 1 | ||
| Ectopic pregnancy* | 2 | 1 | ||
| Mean number of oocyte retrievals | 2.46 (2.30) | - | ||
| Mean number of embryo transfers | 2.16 (1.85) | - | ||
| Mean (SD) months from genetic counseling until successful pregnancy | 12.4 (13.95) | 11.4 (10.9) | NS | |
| Congenital anomaly | 1** | 1 | ||
| Twin pregnancy/live birth | 29.0% (9/31) at 25w (1), 36w (4), 37w (3), 38w (1) | 5.1% (2/39) at 36w (2) | 7.57 (1.50–38.26) | 0.009 |
| Cost/ patient | $7,956 U.S.*** | - |
*Biochemical and ectopic pregnancies were included.
**A fetus with 21 trisomy was terminated at 18 weeks’ gestation.
***The cost is speculated to be lower. The cost ranged from $8,000–10,000 U.S. per trial in other hospitals in Japan. A technical charge was not included in the cost because this study was conducted for clinical research.