Skip to main content
. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Pigment Cell Melanoma Res. 2014 Jul 21;27(6):1075–1085. doi: 10.1111/pcmr.12284

Figure 1.

Figure 1

Sharply demarkated and accelerated depigmentation develops in Vitesse mice. (a) Symmetrical depigmentation patterns of the pelage in Vitesse mice. Littermates, both heterozygous for all 3 transgenes (h3T, HLA-A2 and SCF), showed human-like vitiligo symmetry and complete depigmentation (rather than hair graying observed in h3TA2) at 14 weeks of age. (b) Vitesse mice (n=4) showed significantly accelerated and more complete depigmentation as compared to h3TA2 mice (n=6); Vitesse mice showed half-maximum depigmentation at 14 weeks of age whereas h3TA2 mice showed it at 23 weeks. Depigmentation was calculated for 48 mice total by including individual animals except for time points 30, 35 and 40 weeks calculated for the same Vitesse mice.