Table 1.
Summary of dose modifying factors (DMFs), PF-05212384 (10μM) toxicity alone, and PF-05212384 impact on cell cycle distribution.
| 24 Hr Pre-XRT Treat | 24 Hr Post-XRT Treat | 24 Hour PF-384 (10μM) Exposure (No IR) | ||||
|---|---|---|---|---|---|---|
| DMF (±SEM) | DMF (±SEM) | Surviving Fraction (±SEM) | G1(%)* (Control G1%) | S(%) (Control S%) | G2/M(%) (Control G2/M%) | |
| UMSCC1 | 1.9 (±.07) | 3.6 (±.14) | .71 (±.06) | 88% (39%) | 6% (56%) | 6% (5%) |
| UMSCC46 | 1.0 (±.00) | 1.9 (±.25) | .84 (±.09) | 45% (32%) | 24% (43%) | 31% (25%) |
| 1522 | 1.0 (±.00) | 1.4 (±.15) | .84 (±.06) | 81% (65%) | 3% (21%) | 17% (15%) |
| UMSCC1 (Plateau) | 1.6 (±.05) | 2.2 (±.55) | .62 (±.03) | 87% (69%) | 7% (26%) | 6% (5%) |
*
Cell cycle distribution plots are shown in Supplementary Figure S2. Cell cycle distribution data representative of multiple experiments.