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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Curr Opin Virol. 2015 May 13;12:91–98. doi: 10.1016/j.coviro.2015.04.004

Fig. 4.

Fig. 4

Mechanism by which RIG-I 2CARD nucleates the MAVS CARD filament. In the absence of viral RNA, RIG-I 2CARD exists as a monomer, in which the first and second CARDs form a tight intramolecular interaction. Upon viral RNA binding, 2CARD assembles into a helical tetramer (either mediated by K63-Ubn or filament) that resembles a lock-washer. The 2CARD tetramer nucleates the MAVS CARD filament by recruiting MAVS CARD along the helical trajectory pre-defined by the 2CARD tetramer. Images were adopted from Ref [18].