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. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: Cancer Res. 2015 May 7;75(12):2541–2552. doi: 10.1158/0008-5472.CAN-14-1703

Figure 2. 2. Inhibition of glycolysis attenuates RCC cell viability and lactate production.

Figure 2

(A) 786-O (VHL-mut) and Caki-1 (VHL-wt) cells were treated with media at the indicated glucose concentration, or with the indicated concentration of 2-DG in 5 mM glucose media, for 72 hours and then subjected to MTT assays. *P < 0.05 compared to 5 mM glucose or 0 mM 2-DG. Error bars indicate standard deviation. Data are representative of three repeats.

(B) 786-O (VHL-mut) and Caki-1 (VHL-wt) cells were treated with glucose depleted media (Glc-) or 2-DG (5 mM) for 24 hours then lactate in the media was measured as described in Materials and Methods. *P < 0.05 compared to control (glucose 5 mM). Error bars indicate standard deviation. Data are representative of three repeats.