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A: The cell-killing effect of CPT-VE, CPT-S-S-VE, PEG5K-Fmoc-VE2/CPT-VE and PEG5K-Fmoc-VE2/CPT-S-S-VE with or without GSH (10 mM) in 4T1.2 cancer cell. Cells were treated with indicated concentrations of different CPT formulations for 72 h and cytotoxicity was then assessed by MTT assay. Values reported are the means ± SD for triplicate samples. B: Intracellular release of CPT in 4T1.2 cells treated with CPT-VE and CPT-S-S-VE (100 ng/mL in terms of CPT) for 24 h.
