Figure 1.

Nuclear YAP accumulates in oral tissues with hyperplasia and dysplasia pathology. Tissues from patients exhibiting hyperplasia, mild dysplasia and severe dysplasia, as well as cytologically normal adjacent epithelium, were examined by H&E staining (top panels) and by immunofluorescence to detect YAP localization (the number of tissues examined is indicated). DAPI was used to stain nuclei. A zoomed in image from each sample is shown in the bottom panels, highlighting the YAP localization changes observed. Scale bars represent 20μm.