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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Curr Opin Genet Dev. 2015 Apr 1;32:144–152. doi: 10.1016/j.gde.2015.03.003

Figure 1.

Figure 1

Commitment to the male pathway involves the down-regulation of many genes associated with female development. Diagram depicting the change in the expression of each gene in the XX gonad (X-axis) and XY gonad (Y-axis) between E11.0 and E12.0. Both of these changes can contribute to sexually dimorphic expression. Line graphs show changes in expression of two representative male genes (Dhh and Sox9) and two representative female genes (Msx1 and Wnt4) in the XY (blue line) and XX (red line) gonads. Higher expression of the male pathway genes, Dhh and Sox9, occur primarily through up-regulation in the XY gonad. Sexually dimorphic expression of many of the genes in the female pathway, Msx1 and Wnt4, occurs through down-regulation in the XY gonad. Adapted from Munger SC et al. [11].