. 2015 Feb 22;21:57–63. doi: 10.1007/8904_2014_384

Table 4.

Comparison of pregnancy complications in affected women with FD during pregnancy and the general population of pregnant women

Pregnancy complication	Incidence this cohort of pregnancies	Literature values in Fabry patients from Bouwman et al. (2012)^a and Wang et al. (2007)^b	P value, comparing to literature	General population incidence	P value, comparing to general population
Preeclampsia	4.9% (n = 5/102)	9.4% (n = 3/32)^a	0.35^a	3.4%	0.40
Proteinuria	37.2% (n = 38/102)	34% (n = 11/32)^a	0.76^a	3.8%	<2.2 × 10⁻¹⁶
Proteinuria	37.2% (n = 38/102)	56% (n = 10/18)^b	0.14^b	3.8%	<2.2 × 10⁻¹⁶
Gestational diabetes	8.8% (9/102)	–	–	2–10%	0.002–0.86
Premature delivery	18.8% (16/85)	19% (n = 6/32)^a	0.99^a	11.9%	0.06
Hypertension	10.8% (12/102)	34% (n = 11/32)^a	0.001^a	6%	0.05
Hypertension	10.8% (12/102)	43% (n = 16/37)^b	1.91 × 10^{−5 b}	6%	0.05
Miscarriage	11.8% (11/102)	25% (n = 8/32)^a	0.06^a	9–12%	0.30
Intrauterine death	2.3% (2/85)^c	0.03% (n = 1/32)^a	0.81^a	0.625%	0.09

Symbols denote literature comparisons, Bouwman et al. (2012)^a and Wang et al. (2007)^b. Population incidence of complications is from the CDC (Centers for Disease Control and Prevention National Center for Health Statistics 2012)

^cThese pregnancies were affected by chromosomal abnormalities