Table 2.
Exposure | Cases (74,503) | Controls (744,663) | Odds Ratio (95% CI) | |
---|---|---|---|---|
Crude | Adjusteda | |||
Benzodiazepines | ||||
Long-acting | ||||
None | 68,619 (92.1) | 693,839 (93.2) | 1.00 (reference) | 1.00 (reference) |
New | 87 (0.1) | 807 (0.1) | 1.09 (0.88–1.36) | 1.03 (0.83–1.29) |
Current, not new | 1,718 (2.3) | 13,463 (1.8) | 1.29 (1.23–1.36) | 1.23 (1.16–1.29) |
Past only | 4,079 (5.5) | 36,554 (4.9) | 1.13 (1.09–1.17) | 1.07 (1.04–1.11) |
Short-acting | ||||
None | 58,630 (78.7) | 597,030 (80.2) | 1.00 (reference) | 1.00 (reference) |
New | 138 (0.2) | 1,480 (0.20) | 0.96 (0.80–1.14) | 0.93 (0.78–1.10) |
Current, not new | 5,123 (6.8) | 47,502 (6.4) | 1.11 (1.07–1.14) | 1.05 (1.02–1.08) |
Past only | 10,612 (14.2) | 98,651 (13.2) | 1.10 (1.08–1.13) | 1.05 (1.03–1.08) |
Antidepressants | ||||
Selective serotonin reuptake inhibitors | ||||
None | 72,173 (96.9) | 724,276 (97.3) | 1.00 (reference) | 1.00 (reference) |
New | 93 (0.1) | 690 (0.09) | 1.35 (1.09–1.68) | 1.25 (1.00–1.55) |
Current, not new | 759 (1.0) | 6,166 (0.8) | 1.24 (1.15–1.33) | 1.13 (1.04–1.22) |
Past only | 1,478 (2.0) | 13,531 (1.8) | 1.10 (1.04–1.16) | 1.00 (0.95–1.06) |
Tricyclic antidepressants | ||||
None | 72,264 (97.0) | 724,937 (97.3) | 1.00 (reference) | 1.00 (reference) |
New | 41 (0.06) | 418 (0.06) | 0.98 (0.71–1.36) | 0.93 (0.67–1.28) |
Current, not new | 552 (0.7) | 4,855 (0.6) | 1.14 (1.05–1.25) | 1.04 (0.96–1.14) |
Past only | 1,646 (2.2) | 14,453 (1.9) | 1.14 (1.09–1.20) | 1.05 (0.99–1.10) |
Other antidepressants | ||||
None | 73,705 (98.9) | 738,034 (99.1) | 1.00 (reference) | 1.00 (reference) |
New | 28 (0.04) | 233 (0.03) | 1.20 (0.81–1.78) | 1.10 (0.74–1.63) |
Current, not new | 209 (0.3) | 1,722 (0.2) | 1.22 (1.05–1.41) | 1.09 (0.94–1.26) |
Past only | 561 (0.7) | 4,674 (0.6) | 1.20 (1.10–1.31) | 1.07 (0.98–1.17) |
Values are numbers (percentages) unless stated otherwise
aAdjusted for variables in Table 1
CI confidence interval