Table 3.
Odds ratios of motor vehicle accidents (any) associated with exposure to concurrent use of benzodiazepines and antidepressants combination
| Exposure | Cases (74,503) | Controls (744,663) | Odds ratio (95% CI) | |
|---|---|---|---|---|
| Crude | Adjusteda | |||
| Benzodiazepines (any) and antidepressants | ||||
| Neither | 52,819 (70.9) | 544,069 (73.1) | 1.00 (reference) | 1.00 (reference) |
| Current benzodiazepine, current antidepressantb | 442 (0.6) | 3,302 (0.4) | 1.39 (1.26–1.54) | 1.28 (1.16–1.42) |
| Current benzodiazepine, no antidepressantb | 5,832 (7.8) | 53,675 (7.2) | 1.13 (1.10–1.16) | 1.08 (1.05–1.12) |
| No benzodiazepine, current antidepressantb | 718 (1.0) | 6,712 (0.9) | 1.10 (1.02–1.19) | 1.04 (0.96–1.13) |
| Other combinations | 14,692 (19.7) | 136,905 (18.4) | 1.11 (1.09–1.13) | 1.07 (1.05–1.09) |
| Long-acting benzodiazepines and antidepressants | ||||
| Neither | 64,971 (87.2) | 660,856 (88.7) | 1.00 (reference) | 1.00 (reference) |
| Current long-acting benzodiazepines, current antidepressantb | 163 (0.2) | 1,068 (0.1) | 1.56 (1.32–1.84) | 1.43 (1.21–1.69) |
| Current long-acting benzodiazepines, no antidepressantb | 1,469 (2.0) | 11,896 (1.6) | 1.26 (1.19–1.33) | 1.21 (1.14–1.28) |
| No long-acting benzodiazepine, current antidepressantb | 1,230 (1.6) | 10,923 (1.5) | 1.15 (1.08–1.22) | 1.08 (1.01–1.14) |
| Other combinations | 6,670 (8.9) | 59,920 (8.0) | 1.13 (1.10–1.16) | 1.08 (1.05–1.11) |
| Short-acting benzodiazepines and antidepressants | ||||
| Neither | 64,971 (87.2) | 660,856 (88.7) | 1.00 (reference) | 1.00 (reference) |
| Current short-acting benzodiazepines, current antidepressantb | 304 (0.4) | 2,373 (0.3) | 1.31 (1.16–1.47) | 1.19 (1.06–1.34) |
| Current short-acting benzodiazepines, no antidepressantb | 523 (0.7) | 4,294 (0.6) | 1.24 (1.13–1.36) | 1.10 (0.99–1.22) |
| No short-acting benzodiazepines, current antidepressantb | 911 (1.2) | 8,183 (1.1) | 1.13 (1.06–1.21) | 1.06 (0.99–1.14) |
| Other combinations | 7,794 (10.5) | 68,957 (9.3) | 1.15 (1.12–1.18) | 1.06 (1.02–1.11) |
Values are numbers (percentages) unless stated otherwise
aAdjusted for variables in Table 1
bNew users and current, not new users were grouped in current users, because of small group size
CI confidence interval