Table 4.
Odds ratios of motor vehicle accidents (any) associated with exposure to concurrent use of long-acting benzodiazepine and antidepressants combination
| Exposure | Cases (74,503) | Controls (744,663) | Odds ratio (95% CI) | |
|---|---|---|---|---|
| Crude | Adjusteda | |||
| Long-acting benzodiazepines and SSRIs (any) | ||||
| Neither | 66,824 (89.7) | 677,643 (91.0) | 1.00 (reference) | 1.00 (reference) |
| Current long-acting benzodiazepines, current SSRIb | 69 (0.09) | 456 (0.06) | 1.54 (1.20–1.98) | 1.37 (1.07–1.77) |
| Current long-acting benzodiazepines, no SSRIb | 1,656 (2.2) | 13,194 (1.8) | 1.27 (1.21–1.34) | 1.22 (1.15–1.28) |
| No long-acting benzodiazepine, current SSRIb | 638 (0.9) | 5,493 (0.7) | 1.18 (1.08–1.28) | 1.10 (1.01–1.19) |
| Other combinations | 5,316 (7.1) | 47,877 (6.4) | 1.13 (1.09–1.16) | 1.07 (1.03–1.10) |
| Long-acting benzodiazepines and TCAs (any) | ||||
| Neither | 66,937 (89.8) | 678,609 (91.1) | 1.00 (reference) | 1.00 (reference) |
| Current long-acting benzodiazepines, current TCAb | 79 (0.1) | 489 (0.07) | 1.65 (1.30–2.09) | 1.54 (1.21–1.95) |
| Current long-acting benzodiazepines, no TCAb | 1,608 (2.2) | 12,916 (1.7) | 1.26 (1.20–1.33) | 1.21 (1.14–1.27) |
| No long-acting benzodiazepine, current TCAb | 435 (0.6) | 4,036 (0.5) | 1.10 (0.99–1.21) | 1.03 (0.93–1.14) |
| Other combinations | 5,444 (7.3) | 48,613 (6.5) | 1.14 (1.10–1.17) | 1.08 (1.05–1.11) |
| Long-acting BDZ and other antidepressants | ||||
| Neither | 68,032 (91.3) | 688,741 (92.5) | 1.00 (reference) | 1.00 (reference) |
| Current long-acting benzodiazepines, current other antidepressantb | 24 (0.03) | 145 (0.02) | 1.68 (1.09–2.59) | 1.49 (0.97–2.31) |
| Current long-acting benzodiazepines, no other antidepressantb | 1,739 (2.3) | 13,841 (1.9) | 1.27 (1.21–1.34) | 1.21 (1.15–1.28) |
| No long-acting benzodiazepine, current other antidepressantb | 180 (0.2) | 1,511 (0.2) | 1.21 (1.03–1.41) | 1.11 (0.95–1.29) |
| Other combinations | 4,528 (6.1) | 40,425 (5.4) | 1.14 (1.10–1.17) | 1.07 (1.04–1.11) |
Values are numbers (percentages) unless stated otherwise
aAdjusted for variables in Table 1
bNew users and current, not new users were grouped in current users, because of small group size
CI confidence interval, SSRI selective serotonin reuptake inhibitors, TCA tricyclic antidepressants