Table 2. Relative abundance of common nasopharyngeal bacterial 16S rRNA sequence types.

Taxa	All Subjects	PHiD-CV Group (N = 25) a		Control Group (N = 29) a		Day 180-Day0
	Day 0	Day 0	Day 180	Day 0	Day 180	Comparison (p-value) b
Proteobacteria	56.9% (33.7–70.6)	58.6% (31.4–70.2)	61.7% (46.2–78.3)	53.8% (36.1–70.6)	57.1% (43.6–69.8)	0.74
Haemophilus influenzae	1.6% (0–9.8)	1.6% (0–7.9)	1.0% (0–4.9)	2.0% (0–13.8)	2.5% (0–12.6)	0.85
Moraxella catarrhalis	12.3% (3.7–24.5)	15.7% (3.4–28)	12% (1–24.6)	9.2% (3.7–18.8)	4.2% (1.4–13.1)	0.65
Moraxella nonliquefaciens	2.1% (0.6–10)	2.5% (1.2–9.5)	4.0% (0.8–14)	1.4% (0.3–10.2)	2.4% (0.1–8.9)	0.47
Firmicutes	25.9% (15–46.8)	20.1% (11.8–44.8)	18.2% (8.6–46.6)	26.6% (19.9–46.9)	31.6% (15.6–41.2)	0.66
Streptococcus pneumoniae	4.4% (0.2–25.4)	4.0% (0.3–32.3)	10.3% (0.4–37.7)	4.9% (0–21.1)	10% (0.9–35.3)	0.67
Actinobacteria	7.8% (1.8–21.6)	8.5% (1.5–15.8)	5.1% (0.9–9.2)	6.9% (2.3–22.1)	2.1% (0.5–15.2)	0.18
Corynebacterium spp.	5.6% (1.7–19.8)	8.5% (0.9–15.4)	3.8% (0.8–7.7)	5.2% (2–21.1)	2.1% (0.4–15.1)	0.45
Bacteroidetes	0.4% (0.1–3.8)	0.7% (0.2–4.1)	1.0% (0–4.2)	0.3% (0.1–2.4)	0.3% (0–3.3)	0.92
Other Phyla	0% (0–0.2)	0% (0–0.3)	0.1% (0–0.2)	0.1% (0–0.2)	0% (0–0.2)	0.15
Sequences per specimen	3730	2104	2605	4939	2678	0.35
(Interquartile range)	(1649–9799)	(1146–9587)	(1610–7393)	(2231–10112)	(856–7046)
Good’s Coverage	99.58%	99.60%	99.70%	99.60%	99.80%	0.96
Shannon Diversity	2.91	2.71	2.75	2.92	2.46 c	0.29

^a Median relative abundances of sequences classified for most abundant phyla and selected species.

^b PHiD-CV group vs control group; p-values for comparison of the change in relative abundances over time are from the results of the multiple permutation t-test; p-values for “Sequences per Specimen”, “Good’s Coverage”, and “Shannon Diversity” are from 2-tailed t-test.

^c P = 0.02 for Day 180 vs Day 0 comparison of control group. P = 0.85 for PHiD-CV comparison of Day 180 vs Day0.