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. Author manuscript; available in PMC: 2015 Jun 18.
Published in final edited form as: Bone Tissue Regen Insights. 2014 Nov 12;5:25–35. doi: 10.4137/BTRI.S12331

Figure 5.

Figure 5

Schematic showing a tissue engineering strategy for liver cells based on electrospun nanofibers. The high metabolic demand and liver-specific functions (absorption, detoxification, etc.) of hepatocytes requires a highly perfused tissue structure. Electrospun scaffolds (lower panel) allow excellent hepatocyte perfusion and are desirable options for BAL–assisted devices, tissue engineering for liver regeneration, and hepatocyte culture for drug safety analysis. In a series of studies, Feng and colleagues have developed one such method based on chitosan nanofibers in an attempt to mimic the natural liver lobule structure.72,96 Bar is 25 μm. The diagrams in this figure are adapted from OpenStax College, Anatomy & Physiology. OpenStax CNX. Jul 31, 2014. http://cnx.org/contents/14fb4ad7-39a1-4eee-ab6e-3ef2482e3e22@6.27@6.27.