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. Author manuscript; available in PMC: 2015 Dec 11.
Published in final edited form as: Nature. 2015 Jun 3;522(7555):236–239. doi: 10.1038/nature14503

Extended Data Figure 10. Affect of CHMP2A depletion on NE discontinuities.

Extended Data Figure 10

A. Presentation of reconstructed tomograms from Figure 4D. B. CHMP2A-depelted cells exhibited more non-NPC discontinuities per unit area whilst the number of NPC per unit area was constant, tomograms as described in Figure 4E were scored for discontinuities. The internal diameter of NPCs was slightly reduced in CHMP2A-depleted cells (Control 84 ± 7.6 nm, CHMP2A-1, 74 ± 8.8 nm; CHMP2A-2, 74 ± 5.7 nm). C. Schematic depicting topological equivalent of ESCRT-III-dependent membrane fusion events.