Table 1. Demographic, clinical, biochemical characteristics, echocardiographic measurement, cardiac magnetic resonance (CMR) T2*, time-domain and frequency-domain HRV parameters of non-transfusion dependent thalassemia (NTDT) patients (n = 99).
| Parameters | Median (25th, 75th percentile) |
|---|---|
| Age (years) | 23.00 (17.00, 32.75) |
| Gender | |
| Male (n (%)) | 35 (35.4%) |
| Female (n (%)) | 64 (64.6%) |
| Splenectomy (%) | 35 (35.4%) |
| Number of blood transfusions in last 12 months | 0.00 (0.00, 1.00) |
| Mean hemoglobin in last 12 months (g/dL) | 7.80 (7.10, 8.78) |
| Hematocrit (%) | 25.10 (22.00, 28.80) |
| MCV | 64.90 (59.50, 71.10) |
| Mean ferritin in last 12 months (ng/dL) | 673.50 (318.00, 1009.25) |
| Maximum ferritin in the past 5 years (ng/dL) | 849.00 (396.00, 1925.00) |
| NTBI (μM) | 3.15 (1.11, 6.59) |
| LPI (μM) | 1.12 (0.01, 1.93) |
| Echocardiographic values | |
| LVEDD (mm) | 4.90 (4.50, 5.30) |
| LVESD (mm) | 3.10 (2.88, 3.40) |
| LVEF (%) | 65.80 (61.79, 70.10) |
| FS (%) | 36.20 (32.75, 39.50) |
| CMR T2* (ms) | 43.95 (39.68, 48.75) |
| HRV-Time domain | |
| SDNN (ms) | 114.00 (95.00, 142.00) |
| SDANN (ms) | 105.00 (86.00, 130.00) |
| ASDNN (ms) | 43.00 (37.00, 56.00) |
| rMSSD (ms) | 25.00 (18.00, 35.00) |
| HRV-Frequency domain | |
| LF (ms2) | 14.98 (11.54, 18.35) |
| HF (ms2) | 11.17 (7.66, 16.60) |
| LF/HF ratio | 1.39 (1.16, 1.61) |
NTBI, non-transferrin-bound iron; LPI, labile plasma iron; SDNN, standard deviation of all normal sinus R-R intervals in the entire 24-h recording; SDANN, standard deviation of all averaged normal sinus R-R intervals for all 5-min segment in the 24-h recordings; ASDNN, average of the standard deviations of all R-R intervals for all 5-min segments in the 24-h recordings; rMSSD, root mean square of the mean of the squared difference of two consecutive R-R intervals; LF, low frequency power; HF, high frequency power; LF/HF ratio, ratio of power in low/high frequency.