Spontaneous alternation measures in the Y-maze after delivery of drug or vehicle (cyclodextrin or PBS). Average percent alternation [Alternation (%), left] and alternation rate divided by the number of arm entries (Alt/Arm Entries, right) are shown for each age and drug dose. A, Alternation (%) and Alt/Arm entries for animals receiving CX614. B, Alternation (%) and Alt/Arm entries for animals receiving CX929. C, Alternation (%) and Alt/Arm entries for animals receiving BIC. Asterisks denote significant group differences: *p < 0.05; **p < 0.01. Number of subjects per group ranges from 6 to 13.