Figure 9.
Averaged normalized timelines for LTP experiments in the presence and absence of 5 μm CX614. All slices were prepared at P17–P19 except where noted. Stimulating and recording electrodes were placed the same as for baseline transmission experiments and baseline responses were set to elicit a 1 mVPS. A 20 Hz burst (100 pulses) was applied at time 0. Thick bar denotes CX614 delivery. Inset shows overlaid averaged traces (10 sweeps each) during baseline and at 36–40 min after induction for experiments on slices prepared at P17–P19. Scale bars, 1 mV, 10 ms. Number of slices per group ranges from 8 to 16.