. Author manuscript; available in PMC: 2015 Jun 18.

Published in final edited form as: J Clin Psychiatry. 2014 Jul;75(7):738–747. doi: 10.4088/JCP.13m08727

Table 1.

Clinical and Demographic Characteristics of Sample by Model

	Baseline				2 Weeks				4 Weeks

	Response (N=2,512)		Remission (N = 2,477)		Response (n=l,641)		Remission (n=l,857)		Response (n = 991)		Remission (n=l,262)

Continuous Variables	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Age, y	41.70	13.06	41.66	13.04	42.18	1.13	41.75	13.06	42.65	13.45	42.23	13.07
Age at onset of MDD, y	25.23	14.17	25.20	14.14	25.55	14.37	24.98	14.04	25.39	14.83	25.05	14.40
Length of MDD, y	16.44	13.29	16.44	13.30	16.60	13.52	16.74	13.36	17.23	13.73	17.18	13.51
Years of education	13.73	3.22	13.73	3.22	13.78	3.17	13.85	3.21	13.79	3.16	13.89	3.17
Categorical variables
Income category^a	1.49	1.13	1.51	1.13	1.49	1.14	1.49	1.13	1.46	1.14	1.47	1.13
Week 2
Side effect intensity^b					1.98	1.66	1.97	1.64	1.89	1.58	1.89	. 1.58
Side effect frequency^b					2.02	1.90	2.01	1.88	1.96	1.87	1.94	1.83
Side effect burden^b					1.37	1.48	1.33	1.44	1.26	1.35	1.23	1.31
Symptom improvement^c					1.27	1.04	1.49	1.08	1.08	1.01	1.40	1.07
Week 4
Side effect intensity^b									1.84	1.64	1.83	1.62
Side effect frequency^b									1.88	1.89	1.88	1.88
Side effect burden^b									1.28	1.41	1.25	1.39
Symptom improvement^c									1.34	1.06	1.69	1.07
Binary variables	n	%	n	%	n	%	n	%	n	%	n	%

Employed	1,563	63	1,563	63	990	61	1,139	62	581	60	758	61
Male gender	918	37	904	36	620	38	688	37	376	38	470	37
Hispanic	291	11	289	12	182	11	206	11	110	11	139	11
Race
White	2,035	81	2002	81	1,360	83	1,543	83	817	82	1049	83
Black	416	16	414	17	249	15	277	15	152	15	187	15
Family history of MDD	1,393	56	1,368	56	906	56	1,046	57	546	55	710	57
Suicide attempts	423	17	418	17	278	17	323	17	168	17	222	18
Axis I comorbidity
OCD	272	11	270	11	167	10	192	10	94	10	129	10
PTSD	420	17	416	17	276	17	318	17	173	18	227	18
Bulimia	307	12	305	12	210	13	238	13	132	13	185	15
Panic disorder	265	11	261	11	170	10	190	10	100	10	122	10
Agoraphobia	233	09	228	09	144	09	171	09	79	08	108	09
Social phobia	701	28	694	28	460	28	545	29	289	29	377	30
Alcohol dependence	254	10	251	10	172	11	190	10	115	12	134	11
Substance dependence	158	06	156	06	103	06	118	06	64	06	77	06
GAD	498	20	490	20	340	21	389	21	208	21	260	21
Somatization disorder	47	02	47	02	33	02	34	02	18	02	24	02
Hypochondriasis	89	04	88	04	61	04	66	04	32	03	38	03
Primary care	913	36	901	36	546	33	615	33	302	30	377	30
Marital status
Married	888	35	871	35	592	36	656	35	356	36	443	35
Never married	716	29	710	29	454	28	530	29	270	27	351	28
Divorced	479	19	474	19	312	19	358	19	189	19	247	20
Widowed	76	03	74	03	56	03	61	03	38	04	44	03
Cohabitant	197	08	196	08	122	07	140	08	74	07	94	07
Separated	155	06	151	06	105	06	112	06	64	06	83	07
Academic degree
Lower than high school	266	11	263	11	169	10	181	10	97	10	120	10
High school degree	1,515	60	1,494	60	986	60	1,116	60	602	61	755	60
Higher than high school	730	29	719	29	486	30	560	30	292	29	387	31
History of SSRI resistance	204	09	203	09	133	09	147	09	92	11	117	10
History of antidepressant resistance	272	11	268	11	183	12	200	11	128	13	159	13
Response
QIDS (week 2)							248	13			138	11
QIDS (week 4)											232	18
HDRS (week 12)	1,339	53			783	48			416	42
Remission
QIDS (week 2)					32	02			21	02
QIDS (week 4)									29	03
HDRS (week 12)			1,023	41			709	38			410	32

Categories: 0=< $10,000; 1 = $10,000–$20,000; 2 = $20,000–$40,000; and 3 = > $40,000.

Side effects measured on a 7-point scale from 0 = none to 6 = intolerable.

QIDS improvement measured in categories: −1 = decrease, 0 = 0%–10%, 1 = 10%–20%, 2 = 20%–33%, 3 = 33%–49%.

Abbreviations: GAD = generalized anxiety disorder, HDRS = Hamilton Depression Rating Scale, MDD = major depressive disorder, OCD = obsessive-compulsive disorder, PTSD = posttraumatic stress disorder, QIDS = Quick Inventory of Depressive Symptomatology, SSRI = selective serotonin reuptake inhibitor.