Table 1.
Characteristics of major human and murine mast cell proteases.
| Protein designation | Mast cell subtype | Chromosomal location | Gene name | Primary substrate specificity | Subunit structure |
|---|---|---|---|---|---|
| Chymase | |||||
|
| |||||
| Human | |||||
| Chymase (CMA1) | MCTC | 14q11.2 | CMA1 | Chymotrypsin-like (aromatic amino acid) | Monomer |
|
| |||||
| Mouse | |||||
| mMCP-1 | MMC | 14C1/2 | Mcpt1 | Chymotrypsin-like (aromatic amino acid) | Monomer |
| mMCP-2 | MMC | 14C1/2 | Mcpt2 | Unknown (low enzymatic activity) | Monomer |
| mMCP-4 | CTMC | 14C1/2 | Mcpt4 | Chymotrypsin-like (aromatic amino acid) | Monomer |
| mMCP-5 | CTMC | 14C1/2 | Cma1/Mcpt5 | Elastase-like (Val/Ala/Ile) | Monomer |
|
| |||||
| Tryptase | |||||
|
| |||||
| Human | |||||
| Tryptase βII/βIII (human) | MCTC/MCT | 16p13.3 | TPSB2 | Trypsin-like (Arg/Lys) | Tetramer |
| Tryptase αI/βI (human) | MCTC/MCT | 16p13.3 | TPSAB1 | Trypsin-like (Arg/Lys) | Tetramer |
|
| |||||
| Mouse | |||||
| mMCP-6 | CTMC | 17A3.3 | Mcpt6 | Trypsin-like (Arg/Lys) | Tetramer |
| mMCP-7 | CTMC | 17A3.3 | Tpsab1 | Trypsin-like (Arg/Lys) | Tetramer |
|
| |||||
| Carboxypeptidase A3 | |||||
|
| |||||
| Human | |||||
| MC-CPA | MCTC | 3q24 | CPA3 | CPA-like (C-terminal aromatic/aliphatic amino acids) |
Monomer |
|
| |||||
| Mouse | |||||
| MC-CPA | CTMC | 3A3 | Cpa3 | CPA-CPA-like (C-terminal aromatic/aliphatic amino acids) |
Monomer |