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. 2015 May 5;5(5):e562. doi: 10.1038/tp.2015.55

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Copyright © 2015 Macmillan Publishers Limited

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Effects of tropomyosin-related kinase B (TrkB) reduction on hippocampal expression of glutamate receptor subunits in 5XFAD mice. (a, c) Representative immunoblots of protein extracts from hippocampal homogenates of mice. (b, d) Immunoreactive bands were quantified and expressed as the percentage of wild-type control mice (n=3–6 mice per group). Note that 5XFAD mice at 4–5 months of age have not yet showed significant changes, while reductions in all of the AMPA and NMDA receptor subunits are observed specifically in TrkB^+/–·5XFAD mice (*P<0.05 vs wild type, ^#P<0.05 vs 5XFAD). All data are presented as mean±s.e.m.