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. 2015 May 12;5(5):e565. doi: 10.1038/tp.2015.56

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MicroRNA expression patterns in neural stem cell models of gene dosage disorders are more characteristic of differentiating non-target cells than proliferating non-target cells. (a) NanoString expression values for all microRNA with single point P-values <0.05 in the MBD5 KD experiment compared with non-target proliferating cells. (b) NanoString expression values for the same microRNAs identified in the MBD5 KD experiment but showing values for the cell state (differentiating non-target cells compared with proliferating non-target cells) experiment. (c and d) Quantitative PCR (qPCR) validation of two microRNAs identified in the MBD5 KD experiment. (e) NanoString expression values for all microRNA with single point P-values <0.05 in the SATB2 KD experiment (f) NanoString expression values for the same microRNAs identified in the SATB2 KD experiment, but showing values for the cell state (differentiating non-target cells compared with proliferating non-target cells) experiment. (g and h) qPCR validation of two microRNAs identified in the SATB2 KD experiment. (i) Distribution of microRNAs that are up- or downregulated in the cell state experiment plotted as a function of P-value. KD, knockdown; MBD, methyl-CpG binding domain; SATB, special AT-rich binding protein.