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. 2015 May 12;5(5):e565. doi: 10.1038/tp.2015.56

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Molecular model for neurodevelopmental disorders. Genes with mutations associated with NDDs might affect specific cell processes such as protein translation or chromatin modification in such a way as to impact pathways important in NSC proliferation or differentiation, such as the WNT signaling pathway. The measureable outcome of different genetic variation associated with NDDs may be NSCs with altered regulation of the balance between NSC proliferation and differentiation. These vulnerabilities, specific to each mutation associated with NDDs, might affect the timing of neural stem cell differentiation causing neurons to connect inappropriately in a neural circuit or respond uncharacteristically to attractant or repellent cues. NDD, neurodevelopmental disorder; NSC, neural stem cell.