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. 2015 May 5;5(5):e563. doi: 10.1038/tp.2015.57

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Copyright © 2015 Macmillan Publishers Limited

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There is a significant relationship between the log-transformed t_1/2 (Ln (t_1/2)) of SSRIs vs the RR SREs for the given SSRI in adults (a) and children and adolescents (b). A thorough literature search uncovered t_1/2 data of six SSRIs for adult analysis (fluoxetine, citalopram, venlafaxine, sertraline, paroxetine and fluvoxamine) and four SSRIs for pediatric analysis (fluoxetine, citalopram, sertraline and paroxetine). A significant positive correlation was observed between the two factors in both populations (P<0.05). There is also a significant relationship between the inverse of the time to 90% (1/(T90%)) of maximum concentration (C_max) of that drug when it is administered on a constant dosing schedule and the risk of SREs (c, P<0.05). RR SRE, relative risk of suicide-related event; SSRI, selective serotonin reuptake inhibitor.