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. 2015 May 19;5(5):e569. doi: 10.1038/tp.2015.60

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Copyright © 2015 Macmillan Publishers Limited

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Altered NMDA receptor (NMDAR) subunit protein expression in the hippocampus of Disc1tr Hemi mice. Figures show expression levels of NMDAR subunits GluN2A, GluN2B and GluN1 in hippocampus (a–c) and prefrontal cortex (PFC, d–f) of Disc1tr Hemi mice (n=7) relative to wild type (Wt, n=7) littermates. Data were normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and are shown as mean±s.e.m. *P<0.05, significantly different from Wt (t-test). In the hippocampus, levels of GluN2A (P=0.01) and GluN2B (P=0.04) were significantly lower in Disc1tr Hemi mice compared with Wt littermates. There was a non-significant trend for GluN1 to be higher in the hippocampus of Disc1tr Hemi mice (P=0.057). In the PFC there were no significant differences between the two genotypes (P>0.05).