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. 2015 May 26;5(5):e573. doi: 10.1038/tp.2015.66

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Copyright © 2015 Macmillan Publishers Limited

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Ketamine treatment induces changes in HPLC measured levels of (a–d) glutamate (GLU) and (e–h) aspartate. IMP-KET and FLX-KET increase in GLU levels compared with untreated animals in NAc (both P<0.01) (a). Treatment in IMP-KET and FLX-KET increases aspartate levels in PFC (P< 0.05) (f). FLX, fluoxetine; IMP, imipramine; KET, ketamine; NAc, nucleus accumbens; PFC, prefrontal cortex. Mean±s.e.m., n=7, *P<0.05; ***P<0.001.