Figure 3.

The behaviors scored by computer (A) (percentage of immobility time) and manually (B) (frequency of immobility, swimming, climbing) of rats after acute sarcosine (560 mg/kg, i.p.) administration with pretreatment with NBQX (10 mg/kg, i.p.) or rapamycin (20 mg/kg, i.p.) in FST test. Note that the decreased immobility and increased climbing resulted from acute sarcosine treatment is blocked when rats were pretreated with rapamycin. Similar effect is evidently observed when rats were pretreated with NBQX. (*p < 0.05; **p < 0.01 compared with saline/saline-treated group; ^#p < 0.05, ^##p < 0.01 compared with saline/sarcosine-treated group with Tukey post hoc analysis, Values shown are mean ± SEM, n = 8–9 per group).