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. 2015 Jun 18;9:162. doi: 10.3389/fnbeh.2015.00162

Figure 4.

Figure 4

Representative Western blotting (A) and relative expression ratio of pmTOR (B), pERK (C), and pAkt (D) in the hippocampus of rats after acute sarcosine (560 mg/kg, i.p.) administration with pretreatment with NBQX (10 mg/kg, i.p.) or rapamycin (20 mg/kg, i.p.). Western blots analysis shows a notably increased expression of pmTOR, pERK, and pAkt in rat hippocampus following acute sarcosine treatment. Note that the increased expression of pmTOR, pERK, and pAkt resulted from acute sarcosine treatment is blocked when rats were pretreated with NBQX. The increased expression of pmTOR resulted from acute sarcosine treatment is blocked when rats were pretreated with rapamycin and the increased expression of pERK and pAkt resulted from acute sarcosine treatment is not blocked (*p < 0.05; **p < 0.01 compared with saline/saline-treated group; ##p < 0.01, ###p < 0.001 compared with saline/sarcosine-treated group with Tukey post hoc analysis. Values shown are mean ± SEM, n = 4 per group).