Table I.
Characteristics of each study in the meta-analysis.
| Study (year) | No. of patients | No. of MSI-H, % | Period of follow-up, month | Stage distribution, n | No. of intestinal type | Treatment strategy | No. of MSI marker | MSI-H defination | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|
| Fang et al (2012) | 214 | 11.7 | 1–243 | Early, 44 Advanced, 170 | 134 | Surgery II/III;got adjuvant CT | 5 | ≥2 | (6) |
| Corso et al (2009) | 250 | 25.2 | 36–260.9 | Early, 183 Advanced, 67 | 163 | Surgery; no neoadjuvant CT | 5 | ≥2 | (18) |
| Chiaravalli et al (2001) | 185 | 19.5 | NA | All advanced | 108 | Surgery; no neoadjuvant CT | 3, all mono-neoadjuvant | ≥1 | (31) |
| Beghelli et al (2006) | 510 | 16.3 | Until July 2004 | Early, 64 Advanced, 446 | 286 | Surgery; no neoadjuvant CT | 2, all mono-nucleotide | ≥1 | (21) |
| Kim et al (2011) | 476 | 33.8 | 1–57 | Early, 166 Advanced, 310 | 289 | Surgery | 5 | ≥2 | (20) |
| Falchetti et al (2008) | 159 | 17.0 | 8.8–20.4 | Early, 15 Advanced, 144 | 77 | Surgery | 8 | ≥1 mono-nucleotide | (19) |
| Hayden et al (1997) | 101 | 20.8 | NA | Early, 15 Advanced, 66 | 75 | Surgery | 11 | ≥1 | (24) |
| An et al (2005) | 81 | 18.5 | 47–57.7 | Early, 14 Advanced, 67 | 53 | Surgery | 5 | ≥2 | (28) |
MSI-H, high-frequency microsatellite instability; CT, computed tomography; NA, not available.